تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Effect of pegylated interferon on non-responders and relapsers with interferon
Effect of pegylated interferon on non-responders and relapsers with interferon
 
الموضوع : الجهاز الهضمي 
لغة الوثيقة : الانجليزية 
المستخلص : Objectives: To assess whether a combination of pegylated interferon (interferon conjugated with polyethylene glycol) and ribavirin can improve the response rate in patients with chronic hepatitis C who either did not respond to (Non-responders), or had relapsed after responding to (Relapsers) standard interferon and ribavirin combination therapy. Patients and methods: In this prospective study, 20 chronic hepatitis C patients (comprising 16 Non-responders and 4 Relapsers to previous treatment with alpha interferon and ribavirin), were treated with pegylated interferon-2b weekly and ribavirin daily for one year. Eleven patients had genotype 4, eight were of genotype 1 and one patient had genotype 3. Response to treatment was determined based on normalisation of liver enzymes and negative viral load (assessed using qualitative HCV RNA PCR) at end of treatment (ETR) and 6 months off treatment (SVR). Results: Seven patients (35%) achieved normalisation of liver enzymes and negative viral load at the end of treatment. However, only 2 patients (10%) managed to retain these levels after six months off treatment. The latter two patients had been previous Relapsers. Conclusion: Combination of pegylated interferon and ribavirin may be beneficial in previous relapsers with standard interferon-ribavirin combination therapy, but is unlikely to achieve sustained virological response in non-responders. 
ردمد : 2075-0051X 
اسم الدورية : SQU Journal for Scientific Research: Medical Sciences 
المجلد : 4 
العدد : 1 
سنة النشر : 1422 هـ
2002 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, May 12, 2008 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
هشام أكبرAkbar, Hisham باحث رئيسيدكتوراه 
محمود الاحولAl-Ahwal, Mahmoud باحث مشاركدكتوراه 

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