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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Effects of hyperthyroidism on glucose, glutamine and ketone-body metabolism in the gut of the rat Effects of hyperthyroidism on glucose, glutamine and ketone-body metabolism in the gut of the rat |
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الموضوع |
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الكيمياء الحيوية |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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1. The metabolism of glucose, glutamine and ketone-bodies was studied in the small intestine of rats after 5 days of hyperthyroidism. 2. Portal-drained visceral bloodflow increased by 20.1% (P < 0.05) in hyperthyroid rats and was accompanied by a decrease in the arteriovenous concentration difference of glutamine (25.7%, P < 0.05), glutamate (22.0%, P < 0.05), alanine (20.9%, P < 0.05) and ammonia (20.6%, P < 0.05) and an increase in that of glucose (27.2%, P < 0.05), lactate (28.9%, P < 0.05) and ketone-bodies (163.2%, P < 0.001). 3. The gut of hyperthyroid rats showed increased rates of extraction of glucose, lactate and ketone-bodies. 4. Enterocytes isolated from hyperthyroid rats showed increased rates of utilization of glucose and ketone-bodies but that of glutamine were decreased. 5. The maximal activities of hexokinase, 6-phosphofructokinase, pyruvate kinase, citrate synthase and oxoglutarate dehydrogenase were increased (by 13.7-36.2%) in intestinal mucosal scrapings of hyperthyroid rats, whereas the activity of glutaminase was decreased (22.1-31.4%). 6. It is concluded that hyperthyroidism increases the rates of utilization of glucose and ketone-bodies but decreases that of glutamine (both in vivo and in vitro) by the epithelial cells of the small intestine |
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ردمد |
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0020-711X |
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اسم الدورية |
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The International Journal of Biochemistry |
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المجلد |
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25 |
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العدد |
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4 |
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سنة النشر |
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1413 هـ
1993 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Monday, December 5, 2011 |
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الباحثون
| محمد العرضاوي | Ardawi, Mohammed | باحث رئيسي | دكتوراه | |
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