تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Lack of BCR/ABL reciprocal fusion in variant Philadelphia chromosome translocations: a use of double fusion signal FISH and spectral karyotyping.
Lack of BCR/ABL reciprocal fusion in variant Philadelphia chromosome translocations: a use of double fusion signal FISH and spectral karyotyping.
 
لغة الوثيقة : الانجليزية 
المستخلص : Of all Philadelphia (Ph) producing translocations in CML 5-10% are variant Ph translocations. It is unclear whether they occur subsequent to the classic t(9;22), or occur de novo. The molecular consequences of Ph translocations in CML result in a p210, p190 or a p230 BCR/ABL fusion gene (M-bcr, m-bcr or µ-bcr). The molecular breakpoints in the classic and variant Ph translocations cluster to the same molecular regions. Using G-banding, spectral karyotyping (SKY) and double fusion signal fluorescence in situ hybridization (D-FISH) on metaphases from ten variant Ph translocations, the chromosomal location of the BCR and ABL genes was investigated. All patients had the M-bcr breakpoint: nine had a translocation, one had a translocation and an associated insertion of the BCR/ABL fusion signal into the derivative 9. For the nine patients with a BCR/ABL fusion gene on the derivative 22 the reciprocal ABL and BCR signals were either retained on separate chromosomes, or were deleted from the karyotype. The overall duration of chronic phase was slightly shorter (31.2 months) than expected for standard CML. This study provides a more comprehensive description of the molecular events leading to BCR/ABL fusion and has implications for service laboratories utilizing interphase FISH analysis in CML without confirmatory cytogenetic analysis. 
ردمد : 10865986 
اسم الدورية : Leukemia 
المجلد : 14 
العدد : 6 
سنة النشر : 2000 هـ
2000 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, April 12, 2010 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
جودة المغربيAl-Maghrabi, Jaudah باحث مشاركدكتوراه 

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 26445.doc doc 

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