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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Ultrastructural changes of compressed lumbar ventral nerve roots following decompression Ultrastructural changes of compressed lumbar ventral nerve roots following decompression |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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OBJECTIVE: To study whether there will be a permanent lumbar nerve root scarring or degeneration secondary to continuous compression followed by decompression on the nerve roots, which can account for postlaminectomy leg weakness or back pain.
METHODS: The study was performed at the Department of Anatomy, Faculty of Medicine, King Abdul-Aziz University, Jeddah, Kingdom of Saudi Arabia during 2003-2005. Twenty-six adult male New Zealand rabbits were used in the present study. The ventral roots of the left fourth lumbar nerve were clamped for 2 weeks then decompression was allowed by removal of the clips. The left ventral roots of the fourth lumbar nerve were excised for electron microscopic study.
RESULTS: One week after nerve root decompression, the ventral root peripheral to the site of compression showed signs of Wallerian degeneration together with signs of regeneration. Schwann cells and myelinated nerve fibers showed severe degenerative changes. Two weeks after decompression, the endoneurium of the ventral root showed extensive edema with an increase in the regenerating myelinated and unmyelinated nerve fibers, and fibroblasts proliferation. Three weeks after decompression, the endoneurium showed an increase in the regenerating myelinated and unmyelinated nerve fibers with diminution of the endoneurial edema, and number of macrophages and an increase in collagen fibrils. Five and 6 weeks after decompression, the endoneurium showed marked diminution of the edema, macrophages, mast cells and fibroblasts. The endoneurium was filled of myelinated and unmyelinated nerve fibers and collagen fibrils.
CONCLUSION: Decompression of the compressed roots of a spinal nerve is followed by regeneration of the nerve fibers and nerve recovery without endoneurial scarring |
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ردمد |
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0379-5284 |
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اسم الدورية |
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المجلة الطبية السعودية |
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المجلد |
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27 |
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العدد |
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7 |
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سنة النشر |
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1427 هـ
2006 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Thursday, April 7, 2011 |
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الباحثون
| رائد حمدي | Hamdy, Raid | باحث مشارك | دكتوراه | |
| عبدالمنعم الحياني | Al-Hayani, AbdulMonem | باحث مشارك | دكتوراه | |
| سوسن جلله | Jalalah, Sawsan | باحث مشارك | دكتوراه | |
| محمد الصياد | Al-Sayyad, Mohammed | باحث مشارك | دكتوراه | |
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