تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats
 
الموضوع : علم الأدوية 
لغة الوثيقة : الانجليزية 
المستخلص : Doxorubicin (DOX) is a widely used cancer chemotherapeutic agent. However, it generates free oxygen radicals that result in serious dose-limiting cardiotoxicity. Supplementations with berries were proven effective in reducing oxidative stress associated with several ailments. The aim of the current study was to investigate the potential protective effect of cranberry extract (CRAN) against DOX-induced cardiotoxicity in rats. CRAN was given orally to rats (100mg/kg/day for 10 consecutive days) and DOX (15mg/kg; i.p.) was administered on the seventh day. CRAN protected against DOX-induced increased mortality and ECG changes. It significantly inhibited DOX-provoked glutathione (GSH) depletion and accumulation of oxidized glutathione (GSSG), malondialdehyde (MDA), and protein carbonyls in cardiac tissues. The reductions of cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were significantly mitigated. Elevation of cardiac myeloperoxidase (MPO) activity in response to DOX treatment was significantly hampered. Pretreatment of CRAN significantly guarded against DOX-induced rise of serum lactate dehydrogenase (LDH), creatine phosphokinase (CK), creatine kinase-MB (CK-MB) as well as troponin I level. CRAN alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, CRAN protects against DOX-induced cardiotoxicity in rats. This can be attributed, at least in part, to CRAN's antioxidant activity 
ردمد : 0278-6915 
اسم الدورية : Food and Chemical Toxicology 
المجلد : 48 
العدد : 5 
سنة النشر : 1432 هـ
2010 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Sunday, July 10, 2011 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
هشام موصليMosli, Hisham باحث مشاركدكتوراه 
أيمن ناجيNagy, Ayman باحث مشاركدكتوراه 

الملفات

اسم الملفالنوعالوصف
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