تفاصيل الوثيقة نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : Glutamine and glucose metabolism in human peripheral lymphocytes Glutamine and glucose metabolism in human peripheral lymphocytes   الموضوع : الكيمياء الحيوية  لغة الوثيقة : الانجليزية  المستخلص : The metabolism of glutamine and glucose in resting and concanavalin A-stimulated human peripheral lymphocytes was investigated. Glutamine was metabolized at a high rate by resting and mitogen-stimulated human peripheral lymphocytes and the major end-products of glutamine metabolism were glutamate, aspartate, CO2, and ammonia: the carbon from glutamine may contribute about 21% to respiration. Concanavalin A enhanced the formation of all end-products except glutamate, indicating that more glutamine was metabolized beyond the stage of glutamate in the mitogen-stimulated cells. Mitogenic stimulation caused an increase in the rates of glucose utilization, lactate production and 14CO2 from variously labeled [14C] glucose. Concanavalin A caused an increase in the oxidation of pyruvate as indicated by the enhanced release of 14CO2 from [2-14C]-, [3,4-14C]-, and [6-14C]-glucose. When both glucose and glutamine were presented to the cells, the rates of utilization of both substrates increased and the increased rates of glucose and glutamine utilization could be accounted for mainly by increased rates of lactate and glutamate production, respectively  ردمد : 0026-0495  اسم الدورية : Metabolism  المجلد : 37  العدد : 1  سنة النشر : 1408 هـ 1988 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Saturday, December 3, 2011  الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني محمد العرضاوي Ardawi, Mohammed باحث دكتوراه   الملفات اسم الملف النوع الوصف  31498.pdf pdf   الرجوع إلى صفحة الأبحاث