Document Details

Document Type : Article In Journal 
Document Title :
Pregnancy outcome in connective tissue diseases
Pregnancy outcome in connective tissue diseases
 
Document Language : English 
Abstract : Objective: To describe the pregnancy outcome in women with systemic lupus erythematosus and other connective tissue diseases attending a specialized high risk clinic at the Royal London Hospital. Methods: Retrospective review of 30 patients seen over a 30-month period. Diagnoses included 18 patients with lupus and 5 with mixed connective tissue disease. Patients were evaluated following a standardized protocol. Results: For all patients there were 28 (93%) live births and 2 spontaneous abortions. Of the live births, 6 (21%) were preterms and 5 (17%) were small for gestational age. For the 18-lupus patients there were 17 (94%) live births and one spontaneous abortion. Of the live births, 3 (18%) were preterm, 25% were small for gestational age and one From the Pediatrics Department, The Royal London School of Medicine and Dentistry, Queen Mary Westfield College, University of London, United Kingdom. Received 15th January 2001. Accepted for publication in final form 17th March 2001. Address correspondence and reprint request to: Dr. J. A. Khari, Assistant Professor and Consultant Pediatric Neurologist, Pediatrics Department, King Abdulaziz University Hospital, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia. Tel. +966 (2) 55677904. Fax. +966 (2) 26743781. E-mail: jkari@doctors.org.uk had neonatal lupus erythematosus. Nine patients (30%) were positive for anti Sjogren’s syndrome A antibodies: 7 systemic lupus erythematosus patients (39%) and 2 mixed connective tissue disease patients. Eight patients were positive for anti-phospholipid antibodies: 5 for anticardiolipin and 3 patients for lupus anticoagulant. Conclusion: Most pregnancies complicated by lupus do well with no maternal or neonatal deaths in a multidisciplinary high-risk clinic. However a high rate of prematurity and small gestational age remains a problem 
ISSN : 0379-5284 
Journal Name : Saudi Medical Journal 
Volume : 22 
Issue Number : 7 
Publishing Year : 1422 AH
2001 AD
 
Article Type : Article 
Added Date : Sunday, March 16, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جميلة قاريKari, Jameela ResearcherDoctorate 

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