Document Details

Document Type : Article In Journal 
Document Title :
Familial steroid-responsive nephrotic syndrome and HLA antigens in Bengali children
Familial steroid-responsive nephrotic syndrome and HLA antigens in Bengali children
 
Document Language : English 
Abstract : We investigated the major histocompatibility complex class I and II loci in three Bengali families with nine children affected with steroid-sensitive nephrotic syndrome (SSNS). A sequence-specific primer (SSP) of DNA typing method was used to detect human leukocyte antigens (HLA). The unaffected siblings and their parents were also studied. Similar to previous reports, there was a high frequency of HLA-DR7.1 (DRB1*0701), DR53 (DR B4*01011–0104) and DQ2 (DQB2*0201–3) antigens in the affected children. However, there was a similar finding in the unaffected children and their parents. HLA-DR7.1 probably was not a causative factor, since it had no predictive value for the occurrence or the severity of SSNS in the affected families. Siblings with identical HLA typing behaved differently (they either had or did not have SSNS). In these families there was no correlation between predisposition to the nephrotic syndrome and the genetic determinant responsible for HLA 
ISSN : 0931-041X 
Journal Name : Pediatric Nephrology 
Volume : 16 
Issue Number : 4 
Publishing Year : 1422 AH
2001 AD 
Article Type : Article 
Added Date : Monday, March 31, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جميلة قاريKari, Jameela InvestigatorDoctorate 

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