Document Details

Document Type : Article In Journal 
Document Title :
COMPARISON OF BASAL INSULIN ADDED TO ORAL AGENTS VERSUS TWICE – DAILY PREMIXED INSULIN AS INITIAL INSULIN THERAPY FOR TYPE 2 DIABETES
COMPARISON OF BASAL INSULIN ADDED TO ORAL AGENTS VERSUS TWICE – DAILY PREMIXED INSULIN AS INITIAL INSULIN THERAPY FOR TYPE 2 DIABETES
 
Subject : Endocrinology 
Document Language : English 
Abstract : Objective: To compare the efficacy and safety of adding once – daily basal Glargine insulin versus switching to twice – daily premixed insulin in Type-II diabetic patients not well controlled by combined oral antidiabetic agents. Methods: In a 6 months parallel group clinical trail on 221 patients with Type-II diabetes and poorly controlled on oral antidiabetic agents (fasting blood glucose > 140 mg/ dl and glycosylated hemoglobin >8%) on oral antidiabetic treatment (metformin plus sulfonylurea) were randomized either to add Glargine insulin or to shift them to mixed insulin (30% regular insulin and 70% NPH) twice per day without oral antidiabetic treatment. Insulin dosage was titrated to target fasting blood glucose < 100 mg/dl and predinner blood glucose < 120 mg /dl. Results: Mean hemoglobin A1C decrease from baseline was significantly pronounced (- 2.1 vs. - 1.3 % p = <0.005), and more patients reached HbA1C <7% (57 vs. 31%) with Glargine insulin plus oral antidiabetic treatment than with mixed insulin. The number of patients who achieved the target of fasting blood glucose < 100 mg/dl were more in the group which received Glargine insulin than the other group that received mixed insulin (41.7 vs. 17.8 %). Conclusions: Initiation of insulin therapy in patients with Type-II diabetes uncontrolled on combined metformin and sulfonylurea by adding Glargine insulin was more effective than starting with twice daily of mixed insulin (30% regular insulin and 70% NPH insulin). 
ISSN : 1681-715X 
Journal Name : Pakistan Journal of Medical Sciences 
Volume : 22 
Issue Number : 1 
Publishing Year : 1426 AH
2006 AD 
Article Type : Article 
Added Date : Thursday, October 15, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالرحمن الشيخAl-Shaikh, AbdulRahman ResearcherDoctorate 

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