Document Details

Document Type : Article In Journal 
Document Title :
Bacterial infection and risk factors in outpatients with acute exacerbation of chronic obstructive pulmonary disease: a 2-year prospective study
Bacterial infection and risk factors in outpatients with acute exacerbation of chronic obstructive pulmonary disease: a 2-year prospective study
 
Document Language : English 
Abstract : BACKGROUND AND OBJECTIVES: Acute exacerbations of COPD (AECOPD) are commonly observed in community-based patients worldwide. The factors causing exacerbation are largely unknown. This study was undertaken to determine the predominant bacterial pathogens cultured from sputum in community-based patients with AECOPD, to assess the risk factors associated with exacerbations and to compare these findings with published studies. METHODS: Forty-five patients with stable COPD were prospectively followed in the outpatients' clinic of King Abdulaziz University Hospital. At the first visit, personal data, CXR and measurement of baseline PEF were obtained from each patient. In the subsequent visits, sputum culture and CXR were carried out during exacerbations. RESULTS: Over a period of 24 months, patients made a total of 139 visits for exacerbations, and 69.8% had a positive sputum culture for a single pathogen. Moraxella catarrhalis (25.2%), Pseudomonas aeruginosa (12.2%) and Haemophilus influenzae (11.5%) were the most common isolated organisms. Patients with a lower level of baseline PEF had a significantly increased frequency of exacerbations (r = 0.337, P = 0.024). However, there was a weak correlation between exacerbation frequency and duration of COPD and exposure to cigarette smoking. CONCLUSION: There was a higher incidence of Moraxella catarrhalis and Pseudomonas aeruginosa than reported in previous studies. These findings should influence antibiotic selection for exacerbations. COPD patients with a low baseline PEF are at a higher risk of having repeated exacerbations and gram-negative pathogens 
ISSN : 1323-7799 
Journal Name : Respirology 
Volume : 12 
Issue Number : 2 
Publishing Year : 1428 AH
2007 AD 
Article Type : Article 
Added Date : Friday, October 16, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عمر العموديAlamoudi, Omer ResearcherDoctorate 

Files

File NameTypeDescription
 29093.pdf pdf 

Back To Researches Page