Document Details
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Document Type |
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Article In Journal |
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Document Title |
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EFFECT OF GREEN TEA EXTRACT AND VITAMIN C ON OXIDANT OR ANTIOXIDANT STATUS OF RHEUMATOID ARTHRITIS RAT MODEL EFFECT OF GREEN TEA EXTRACT AND VITAMIN C ON OXIDANT OR ANTIOXIDANT STATUS OF RHEUMATOID ARTHRITIS RAT MODEL |
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Document Language |
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English |
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Abstract |
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Elevated free radical generation in inflamed joints and impaired antioxidant system has been implicated in
rheumatoid arthritis (RA). Green tea extracts (GTE) have been shown to reduce inflammation in inflammatory
arthritis murine model. This study investigates possible mechanisms by which vitamin C and GTE protect
joints in RA rat model. This study included forty adult male rats that were divided into four groups (10 rats
each); control group, collagen II induced RA group (CII), CII treated with vitamin C (CII + Vit C) and CII treated
with GTE (CII + GTE) in physiology laboratory, Assiut University, Egypt. After 45 days of treatment, plasma
levels of lipid peroxides (LPO), nitric oxide (NO), ceruloplasmin (CP), superoxide dismutase (SOD), uric acid
(UA) and glutathione (GSH) were detected using colorimetric methods, PGE2 using ELISA and copper (Cu)
and zinc (Zn) using spectrometer. In CII group, levels of LPO, NO, PGE2, UA, CP, Cu were higher while SOD,
GSH, Zn were lower than controls. In groups treated with vitamin C and GTE, levels of SOD, GSH were
increased while levels of LPO, NO, PGE2, Cu, CP were decreased compared with CII group. Levels of UA
were decreased and Zn increased in GTE treated group compared with CII group. GTE treated group showed
higher Zn and low Cu levels compared with vitamin C treated group. This study suggests proper GTE and
vitamin C intake may effectively normalize the impaired oxidant/ antioxidant system and delaying complication
of RA. |
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ISSN |
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0379-5284 |
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Journal Name |
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Indian Journal of Clinical Biochemistry |
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Volume |
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24 |
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Issue Number |
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3 |
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Publishing Year |
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2009 AH
2009 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, March 17, 2010 |
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Researchers
| خالد عظام | ezam, khaled | Researcher | Doctorate | |
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