Document Details

Document Type : Article In Journal 
Document Title :
THE ROLE OF HHV-8 IN THE PATHOGENESIS OF HIV NEGATIVE CASTLEMAN'S DISEASE: MMUNOHISTOCHEMISTRY ANALYSIS
THE ROLE OF HHV-8 IN THE PATHOGENESIS OF HIV NEGATIVE CASTLEMAN'S DISEASE: MMUNOHISTOCHEMISTRY ANALYSIS
 
Document Language : English 
Abstract : BACHGROUND: Castleman's disease (CD) is a rare atypical lymphoproliferative disorder that is morphologically and clinically heterogeneous and is associated with a risk of developing malignant lymphoma. The pathogenesis of CD is still not clear. The aim of this study is to evaluate the possible involvement of human herpesvirus-8 (HHV-8) in the pathogenesis of CD. METHOD: Immunohistochemistry for HHV-8 was performed on archival formalin- fixed, paraffin wax embedded biopsy specimens from 25 cases of CD without human immunodeficiency virus (HIV) infection at The Toronto General Hospital, University Health Network (Toronto, Canada), King Abdulaziz University Hospital and King Faisal Specialist Hospital and Research Centre (Jeddah, Saudi Arabia). The clinical histories were reviewed. Pathology sections (4 m) were stained using mouse monoclonal antibody (NCL-HHV8-LNA), which is specific for human herpesvirus type 8 latent nuclear antigen-1 (LNA-1). The assays were performed at the Department of Pathology, KAUH, Jeddah, KSA in 2007. RESULTS: The age range was 16-90 years. There were 14 males and 11 females. Twenty-one patients had the localized form of CD and 4 patients had the multicentric form. Only one of the 25 cases (4%) showed positive nuclear staining. CONCLUSIONS: HHV-8 is unlikely to play a significant role in the pathogenesis of the large majority of cases of HIV-negative CD. This is in contrast to the reported involvement of HHV-8 in HIV-positive CD. 
ISSN : 16895621 
Journal Name : The New Egyptian Journal of Medicine 
Volume : 38 
Issue Number : 4 
Publishing Year : 2008 AH
2008 AD 
Article Type : Article 
Added Date : Sunday, April 11, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جودة المغربيAl-Maghrabi, Jaudah InvestigatorDoctorate 

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