Document Details

Document Type : Article In Journal 
Document Title :
HER-2 Positivity and Correlations with other Histopathologic Features in Breast Cancer Patients - Hospital Based Study
HER-2 Positivity and Correlations with other Histopathologic Features in Breast Cancer Patients - Hospital Based Study
 
Document Language : English 
Abstract : Objective: To review HER-2 status and its correlation with all other prognostic histopathological features of all Breast Cancer (BC) patients diagnosed between January 2000 and December 2004 at King Abdul Aziz University Hospital (KAUH) in the western region of Saudi Arabia. Methods: Histopathology specimens were examined by Immunohistochemistry (IHC) and labeled as HER-2/neu positive when Hercep Test score was three plus (3+). Results: HER-2/neu was reported only in 145 patients out of 260. Out of 145 patients, it was positive in 41 patients (28.3%), negative in 104 patients (71.7%). Correlations between HER-2/neu status and age, race and other prognostic histopathologic features revealed: No correlation with age (or ~40 Y vs >40 Y with a p-value of 0.552), race (Saudis vs Non-Saudis with a p-value of 0.133), histopathology subtype (p=0.980), tumor size (p=0.455), number of positive lymph nodes (p=0.660), tumor grade (p=0.062), Iymphovascular invasion (p=0.055) and progesterone receptor (PR) status (p=0.069) but positive correlation only with estrogen receptor status (ER) (p=0.003). Conclusion: HER-2/neu over expression was positive in 28.3% of the tested specimens of BC which is consis¬tent with what was reported in literature. It was found to correlate inversely with ER status. Routine testing is mandatory because of its prognostic value and impact on further management (JPMA 56:65;2006). 
ISSN : 1110-5607 
Journal Name : 1110-5607 
Volume : 56 
Issue Number : 2 
Publishing Year : 1427 AH
2006 AD 
Article Type : Article 
Added Date : Saturday, January 15, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمود الاحولAI-Ahwal, Mahmoud ResearcherDoctorate 

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