Document Details

Document Type : Article In Journal 
Document Title :
Febrile neutropenia comparison between solid tumors and hematological malignancies
Febrile neutropenia comparison between solid tumors and hematological malignancies
 
Document Language : English 
Abstract : Our aim was to study all patients with febrile neutropenia (FN) admitted between April 2000 and December 2003 at King Abdul Aziz University Hospital (KAUH). Data of all patients with FN in solid tumours (ST) and hematological malignancies (HM) were collected and analyzed. A total of 73 admissions of 51 patients admitted with FN (46 admissions with ST and 27 with HM). Seventy four percent were < 50 years of age and 26% > 50 years. Males were 46.6% while females 53.4%. Saudis were 19.2% while non Saudis were 80.8%. Duration of neutropenia was <7days in 43 (58.9%) admissions with ST, 3 (4.1%) admissions with HM while >7days, 3 (4.1%) admissions with ST and 24 (32.9%) with HM (p-value <0.001). Positive cultures were found only in 7 (9.6%) patients with ST vs 18 (24.7%) in HM (p-value <0.001). Positive blood cultures were higher in HM compared to ST (68% vs 16%; p-value 0.053).There was no difference between ST and HM in use of growth factors (p-value 0.606), presence of medical co-morbidity (p-value 0.348) or treatment outcome (p-value 0.137).Twenty one out of 25 positive cultures were found in the blood; 14 with gram-positive bacteria, 5 with gram-negative bacteria, fungal infection in 4 and mixed organisms in 2 cultures. Duration of neutropenia and co-morbidity were the only factors which have leaded to poor outcome. Conclusion: Febrile neutropenia is more common and serious in HM than ST. Culture with gram-positive organisms are higher than gram-negative ones. Pattern of infection varies between hospitals for which each institute should have their own guidelines to manage such cases. 
ISSN : 1012-8832 
Journal Name : Pan Arab Medical Journal 
Volume : 2 
Issue Number : 4 
Publishing Year : 1426 AH
2005 AD 
Article Type : Article 
Added Date : Monday, February 7, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمود الاحولAl-Ahwal, Mahmoud InvestigatorDoctorate 
فاتن السايسAl-Sayes, Fatin ResearcherDoctorate 

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