Document Details Document Type : Article In Journal  Document Title : Fructosamine in obese normal subjects and type 2 diabetes Fructosamine in obese normal subjects and type 2 diabetes   Subject : Diabetes Mellitus  Document Language : English  Abstract : The effect of various grades of obesity on serum fructosamine concentrations was studied in Type 2 diabetic (n = 105) and non-diabetic (n = 128) subjects. In obese diabetic and non-diabetic subjects (body mass index > or = 30 kg m-2), the concentration of fructosamine was markedly lower than that obtained for lean diabetic and non-diabetic subjects with similar glycaemic control. Stepwise multiple-regression analysis showed that fructosamine was associated with glycaemic control (as indicated by fasting plasma glucose and glycated haemoglobin), fasting triglycerides, and body mass index in both diabetic and non-diabetic subjects. In vitro studies showed marked decreases in both the extent of [14C]-glucose incorporation into plasma proteins and fructosamine production by incubated sera of obese patients whether diabetic or non-diabetic, with obese subjects with body mass index > 40 kg m-2 exhibiting the greatest decrease. In conclusion, serum fructosamine concentrations are shown to decrease in obese diabetic and non-diabetic subjects with body mass index > or = 30 kg m-2 giving rise to the underestimation of glycaemic control as indicated by fructosamine measurement. A change in the glycation reaction itself may be partly responsible for such decrease  ISSN : 1464-5491  Journal Name : Diabetic Medicine  Volume : 11  Issue Number : 1  Publishing Year : 1414 AH 1994 AD  Article Type : Article  Added Date : Saturday, April 2, 2011  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email محمد العرضاوي Ardawi, Mohammed Investigator Doctorate   حسن نصرت Nasrat, Hasan Researcher Doctorate   Files File Name Type Description  29487.pdf pdf   Back To Researches Page