|
Document Type |
: |
Article In Journal |
|
Document Title |
: |
Effects of hyperthyroidism on glucose, glutamine and ketone-body metabolism in the gut of the rat Effects of hyperthyroidism on glucose, glutamine and ketone-body metabolism in the gut of the rat |
|
Subject |
: |
Biochemistry |
|
Document Language |
: |
English |
|
Abstract |
: |
1. The metabolism of glucose, glutamine and ketone-bodies was studied in the small intestine of rats after 5 days of hyperthyroidism. 2. Portal-drained visceral bloodflow increased by 20.1% (P < 0.05) in hyperthyroid rats and was accompanied by a decrease in the arteriovenous concentration difference of glutamine (25.7%, P < 0.05), glutamate (22.0%, P < 0.05), alanine (20.9%, P < 0.05) and ammonia (20.6%, P < 0.05) and an increase in that of glucose (27.2%, P < 0.05), lactate (28.9%, P < 0.05) and ketone-bodies (163.2%, P < 0.001). 3. The gut of hyperthyroid rats showed increased rates of extraction of glucose, lactate and ketone-bodies. 4. Enterocytes isolated from hyperthyroid rats showed increased rates of utilization of glucose and ketone-bodies but that of glutamine were decreased. 5. The maximal activities of hexokinase, 6-phosphofructokinase, pyruvate kinase, citrate synthase and oxoglutarate dehydrogenase were increased (by 13.7-36.2%) in intestinal mucosal scrapings of hyperthyroid rats, whereas the activity of glutaminase was decreased (22.1-31.4%). 6. It is concluded that hyperthyroidism increases the rates of utilization of glucose and ketone-bodies but decreases that of glutamine (both in vivo and in vitro) by the epithelial cells of the small intestine |
|
ISSN |
: |
0020-711X |
|
Journal Name |
: |
The International Journal of Biochemistry |
|
Volume |
: |
25 |
|
Issue Number |
: |
4 |
|
Publishing Year |
: |
1413 AH
1993 AD |
|
Article Type |
: |
Article |
|
Added Date |
: |
Monday, December 5, 2011 |
|
Researchers
| محمد العرضاوي | Ardawi, Mohammed | Investigator | Doctorate | |
|