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Document Type |
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Article In Journal |
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Document Title |
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Circulating Levels of Progesterone as Biochemical Evidence of Ovulation is Method Dependent Circulating Levels of Progesterone as Biochemical Evidence of Ovulation is Method Dependent |
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Document Language |
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English |
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Abstract |
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Serum progesterone level is used as an indictor of ovulation and several assays are commercially available for its routine measurement. Target values suggestive of ovulation, deficient luteal phase and anovulation have been proposed and are widely sighted in the literature. In this study, we compared the use of two different assays namely: Amerlite (Johnson & Johnson, United Kingdom), and AxSym (Abbott Diagnostics, Germany) for measurement of serum progesterone. In patients being investigated for infertility (n = 93), serum progesterone levels showed good correlation (r = 0.92) between the two methods; however, values were significantly different (P < 0.005). Using published cut-offs levels for progesterone, 28.3%, 60.8%, and 10.9% of patients had ovulatory, anovulatory, ad deficient luteal phase, respectively, as measured by the Amerlite assay, compared to 32.6%, 60.8%, and 6.5% when using the AxSym assay. Thus when using the AxSym assay, higher percentage of patients would be classified as having ovulaory cycle. This study indicated that methodological differences on their own right play a significant role in the determination of ovulatory statue of patients. The study showed that laboratory-based target values need to be established |
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ISSN |
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1319-1004 |
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Journal Name |
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Medical Science Journal |
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Volume |
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10 |
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Issue Number |
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1 |
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Publishing Year |
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1422 AH
2002 AD |
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Article Type |
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Article |
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Added Date |
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Friday, June 8, 2012 |
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Researchers
| طريف زواوي | Zawawi, Tarif | Researcher | Doctorate | |
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