Document Details Document Type : Article In Journal  Document Title : Fetal liver dysfunction in Rh alloimmunization Fetal liver dysfunction in Rh alloimmunization   Subject : Obstetrics and Gynecology  Document Language : English  Abstract : The liver enzymes, aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP), were measured in the blood of 25 fetuses with severe Rh alloimmunization at the time of their first, second and third intravascular transfusions and in 17 comparison fetuses. In the comparison group, GGT increased with advancing gestation (r = 0.7; P = 0.002), whereas ALP, AST and ALT did not correlate with gestational age. Rh hydropic fetuses (n = 8) had higher blood ALT levels than the comparison fetuses (P = 0.008) had significantly increased transaminases when compared with non hydropic fetuses (n = 17). In hydropic fetuses, AST correlated with the nucleated red cell count before transfusion (r = 0.94; P = less than 0.0001). Fetal transaminases were no longer increased in hydropic fetuses by the second (AST) or third (ALT) transfusion. In both hydropic and non hydropic fetuses, GGT increased by the second transfusion (median percentage change +85%, range -83% to +596%; P = 0.003). The rise in fetal GGT was transitory and correlated with the increase in fetal haematocrit at the first transfusion (r = 0.58; P = 0.006). This study reports liver dysfunction secondary to extramedullary erythropoiesis in Rh alloimmunization and implicates portal hypertension for the rise in fetal GGT with transfusion  ISSN : 0306-5456  Journal Name : The British Journal of Obstetrics and Gynaecology  Volume : 98  Issue Number : 3  Publishing Year : 1411 AH 1991 AD  Article Type : Article  Added Date : Sunday, April 3, 2011  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email حسن نصرت Nasrat, Hasan Researcher Doctorate   Files File Name Type Description  29510.pdf pdf   Back To Researches Page